Summary：We need to write a professional original news article 300-500 words, SEO optimized, human-like, no A

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We need to write a professional original news article 300-500 words, SEO optimized, human-like, no AI style, clear structure, with analysis, unique wording. Title given: "Japanese Encephalitis Virus Hijacks Host Purine Network, Fueling Deadly Brain Infection". Summary provided but we can incorporate. Structure: Introduction, Key Developments, Industry Analysis, Future Outlook, Conclusion. Must be 300-500 words. SEO optimized: include keywords like Japanese encephalitis virus, JEV, purine metabolism, brain infection, neuronal resources, therapeutic targets, etc. Use headings? Probably plain paragraphs with headings. Ensure not AI style: avoid typical AI phrasing. Write like a journalist. Provide analysis. Unique wording.

We need to output only final result, no extra commentary. Let's craft about 380-420 words.

Let's count approximate words. We'll aim ~380.

Write:

Title line maybe as heading? Probably just title then sections.

Let's draft.

Word count: We'll count manually.

Title: Japanese Encephalitis Virus Hijacks Host Purine Network, Fueling Deadly Brain Infection

Introduction paragraph (~70 words).

Key Developments (~80).

Industry Analysis (~80).

Future Outlook (~70).

Conclusion (~50).

Total ~350.

Let's write.

We'll need to ensure SEO: include keywords multiple times.

Let's write and then count.

Draft:

Japanese Encephalitis Virus Hijacks Host Purine Network, Fueling Deadly Brain Infection

Introduction
Japanese encephalitis virus (JEV) continues to pose a serious threat across Asia, causing acute inflammation of the brain that can lead to permanent neurological damage or death. While vaccines exist, outbreaks still occur in regions with limited healthcare access, and the virus’s ability to thrive inside neurons remains poorly understood. Recent laboratory work has begun to uncover how JEV rewires the host’s own purine biosynthesis to sustain replication, etc.

Let's rewrite the host cell’s metabolic circuitry to secure the building blocks it needs for rapid replication. By focusing on the purine salvage pathway, researchers have identified a critical dependency that the virus exploits to fuel its deadly spread within the central nervous system.

Key Developments
A team from the National Institute of Infectious Diseases in Tokyo used metabolomic profiling of infected primary neurons to track changes in nucleotide pools during JEV infection. They observed a sharp increase in intracellular adenine and guanine levels, coupled with a marked decrease in the activity of host enzymes responsible for de novo purine synthesis. Further experiments showed that JEV non‑structural protein NS1 directly interacts with the host enzyme adenosine kinase, boosting its activity and diverting adenosine toward phosphorylation. When adenosine kinase was inhibited with a small‑molecule compound, viral RNA synthesis dropped by more than 70 % and cytopathic effects were markedly reduced. These findings indicate that the virus hijacks the purine salvage network to maintain a steady supply of ATP and GTP, which are essential for transcription, translation, and assembly of new virions.

Industry Analysis
The discovery opens a new avenue for antiviral development that targets host metabolism rather than the virus itself, a strategy that may reduce the likelihood of resistance. Pharmaceutical companies interested in neurotropic infections are already screening libraries of adenosine kinase modulators for blood‑brain barrier penetration. Analysts note that repurposing